Solabegron

Solabegron

• CAS Number: 252920-94-8
• UNSPSC Description: Solabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM[1]. Solabegron (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome[1].
• Target Antigen: Adrenergic Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein;Neuronal Signaling
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease; Endocrinology
• Assay Protocol: https://www.medchemexpress.com/Solabegron.html
• Purity: 99.89
• Solubility: DMSO : ≥ 33.33 mg/mL
• Smiles: O=C(C1=CC(C2=CC=CC(NCCNC[C@@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O
• Molecular Weight: 410.89
• References & Citations: [1]Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9.|[2]Andersson KE, et al. Selective β3-adrenoceptor agonists for the treatment of overactive bladder. J Urol. 2013 Oct;190(4):1173-80.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: Phase 2