Doxepin
CAT:
804-HY-B0725A
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No

Doxepin
- CAS Number: 1668-19-5
- UNSPSC Description: Doxepin inhibits reuptake of serotonin and norepinephrine as a tricyclic antidepressant. Doxepin has therapeutic effects in atopic dermatitis, chronic urticarial, can improve cognitive processes, protect central nervous system. Doxepin has also been proposed as a protective factor against oxidative stress[1][2][3].
- Target Antigen: Akt; mTOR; PI3K
- Type: Reference compound
- Related Pathways: PI3K/Akt/mTOR
- Applications: Neuroscience-Neurodegeneration
- Field of Research: Neurological Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/doxepin.html
- Solubility: 10 mM in DMSO
- Smiles: CN(C)CC/C=C1C2=CC=CC=C2OCC3=CC=CC=C/13
- Molecular Weight: 279.38
- References & Citations: [1]AnnemiekVermeeren, et al. Effects of the use of hypnotics on cognition. Progress in brain research vol. 190 (2011): 89-103.|[2]G Hajak, et al. Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. The Journal of clinical psychiatry vol. 62,6 (2001): 453-63.|[3]Mahsa Gharzi, et al. Effects of different doses of doxepin on passive avoidance learning in rats. Advanced biomedical research vol. 2 66. 30 Jul. 2013. |[4]Jimei Bu, et al. Mechanism underlying the effects of doxepin on β-amyloid -induced memory impairment in rats. Iran J Basic Med Sci. 2017 Sep;20(9):1044-1049.J Appl Toxicol. 2023 Apr 14.|Nat Commun. 2022 Nov 10;13(1):6796.|Cell Commun Signal. 2023 May 25;21(1):123.|Virus Res. 2022 Aug;317:198816.
- Shipping Conditions: Room temperature
- Clinical Information: Launched