Allopurinol-d2

Allopurinol-d2

• CAS Number: 916979-34-5
• UNSPSC Description: Allopurinol-d2 is deuterium labeled Allopurinol. Allopurinol is a potent xanthine oxidase inhibitor (IC50 values of 0.2 to 50 μM). Allopurinol can be used for the research of hyperuricemia and gout. Antileishmanial effect[1][2].
• Target Antigen: Isotope-Labeled Compounds; Xanthine Oxidase
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Applications: COVID-19-immunoregulation
• Field of Research: Infection; Inflammation/Immunology
• Purity: 98.33
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(NN=C2[2H])NC([2H])=N1
• Molecular Weight: 138.12
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Pacher P, et al. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev. 2006 Mar;58(1):87-114.|[3]Pfaller MA, et al. Antileishmanial effect of allopurinol. Antimicrob Agents Chemother. 1974;5(5):469-472.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported