Riluzole-13C,15N2

Riluzole-13C,15N2

• CAS Number: 1215552-03-6
• UNSPSC Description: Riluzole-13C,15N2 is the 13C and 15N labeled Riluzole[1]. Riluzole is an anticonvulsant agent and belongs to the family of use-dependent Na+ channel blocker which can also inhibit GABA uptake with an IC50 of 43 μM[2][3].
• Target Antigen: GABA Receptor; Sodium Channel
• Type: Isotope-Labeled Compounds
• Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/riluzole-13c-15n2.html
• Solubility: 10 mM in DMSO
• Smiles: [15NH2][13C]1=[15N]C2=CC=C(OC(F)(F)F)C=C2S1
• Molecular Weight: 237.18
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]He Y, et al. Neuroprotective agent riluzole potentiates postsynaptic GABA(A) receptor function. Neuropharmacology. 2002 Feb;42(2):199-209.|[3]Thompson JM, et al. Small-conductance calcium-activated potassium (SK) channels in the amygdala mediate pain-inhibiting effects of clinically available riluzole in a rat model of arthritis pain. Mol Pain. 2015 Aug 2811:51.
• Shipping Conditions: Room temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported