Glucosylceramide synthase-IN-4
CAT:
804-HY-163131
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Glucosylceramide synthase-IN-4
- CAS Number: 2776965-41-2
- UNSPSC Description: Glucosylceramide synthase-IN-4 (compound 12) is a potent glucosylceramide synthase (GCS) inhibitor, with an IC50 of 6.8 nM. Glucosylceramide synthase-IN-4 shows excellent PK properties and stability in human hepatocytes. Glucosylceramide synthase-IN-4 has good CNS penetration and acceptable PXR selectivity[1].
- Target Antigen: Glucosylceramide Synthase (GCS)
- Type: Reference compound
- Related Pathways: Neuronal Signaling
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/glucosylceramide-synthase-in-4.html
- Solubility: 10 mM in DMSO
- Smiles: CC1=NN=C(C2=CC=C(C=C2)C3=C4C(N(CC4=CC(F)=C3F)[C@H](C(F)(F)F)C(C)(O)C)=O)O1
- Molecular Weight: 467.39
- References & Citations: [1]H. Marie Loughran, et al. Fluorinated Isoindolinone-Based Glucosylceramide Synthase Inhibitors with Low Human Dose Projections. ACS Med. Chem. Lett. 2024, 15, 1, 123-131.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported