Login

PARP/EZH2-IN-2

CAT:
804-HY-161083
Size:
Inquire
Price:
Ask
For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
PARP/EZH2-IN-2 - image 1

PARP/EZH2-IN-2

  • UNSPSC Description: PARP/EZH2-IN-2 (compound 12e) is a dual target PARP1 and EZH2 inhibitor, with IC50 values of 6.89 and 27.34 nM, respectively. PARP/EZH2-IN-2 shows anticancer activity, with no toxicity to normal cells. PARP/EZH2-IN-2 achieves synthetic lethality indirectly by inhibiting EZH2 to increase the sensitivity to PARP1, and induces cell death by regulating excessive autophagy[1].
  • Target Antigen: Histone Methyltransferase; PARP
  • Type: Reference compound
  • Related Pathways: Cell Cycle/DNA Damage;Epigenetics
  • Applications: Cancer-programmed cell death
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/parp-ezh2-in-2.html
  • Solubility: 10 mM in DMSO
  • Smiles: CC1=CC(C)=C(C(N1)=O)CNC(C2=CC(C3=CC=C(C4=NC5=C(C(N)=O)C=CC=C5N4)C=C3)=CC6=C2C=NN6C(C)C)=O
  • Molecular Weight: 573.64
  • References & Citations: [1]Li X, et al. Dual target PARP1/EZH2 inhibitors inducing excessive autophagy and producing synthetic lethality for triple-negative breast cancer therapy. Eur J Med Chem. 2023 Dec 17;265:116054.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported