RORγt agonist 4
CAT:
804-HY-160021
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
RORγt agonist 4
- CAS Number: 2241769-59-3
- UNSPSC Description: RORγt agonist 4 (compound 14) is a potent and selective agonist of RORγt. RORγt agonist 4 significantly enhances metabolic stability. RORγt agonist 4 improves the situation of tumor models of mouse B16F10 melanoma and LLC lung adenocarcinoma[1].
- Target Antigen: ROR
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/rorγt-agonist-4.html
- Solubility: 10 mM in DMSO
- Smiles: N#CC1=C(OC(C)C)C=CC(C2=C(C=C(NC(CC3=CC=C(S(=O)(CC)=O)C=C3)=O)C=C2Cl)Cl)=C1
- Molecular Weight: 531.45
- References & Citations: [1]Lu L, et al. Discovery of Biaryl Amide Derivatives as Potent, Selective, and Orally Bioavailable RORγt Agonists for Cancer Immunotherapy. J Med Chem. 2023 Nov 20.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported