Tubulin polymerization-IN-49

Tubulin polymerization-IN-49

• UNSPSC Description: Tubulin polymerization-IN-49 (compound 12d) is a potent tubulin polymerization inhibitor. Tubulin polymerization-IN-49 bound to colchicine site on tubulin and inhibited tubulin polymerization. Tubulin polymerization-IN-49 induces cell cycle arrest at G2/M phase and apoptosis. Tubulin polymerization-IN-49 has anticancer active and prevents tumor generation, inhibits tumor proliferation and angiogenesis[1].
• Target Antigen: Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-49.html
• Solubility: 10 mM in DMSO
• Smiles: OC1=C(OC)C=CC(CC2CC3=CC(OC)=C(OC)C(OC)=C3C2)=C1
• Molecular Weight: 344.40
• References & Citations: [1]Xu S, et, al. Design, synthesis and evaluation of dihydro-1H-indene derivatives as novel tubulin polymerisation inhibitors with anti-angiogenic and antitumor potency. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2247579.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported