Thalidomide-5-NH-PEG5-NH2 (hydrochloride)
CAT:
804-HY-156170
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Thalidomide-5-NH-PEG5-NH2 (hydrochloride)
- UNSPSC Description: Thalidomide-5-NH-PEG5-NH2 hydrochloride is the Thalidomide (HY-10984)-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-NH-PEG5-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTACs[1].
- Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-5-nh-peg5-nh2-hydrochloride.html
- Purity: 95.84
- Solubility: 10 mM in DMSO
- Smiles: O=C1NC(C(CC1)N2C(C3=CC=C(NCCOCCOCCOCCOCCOCCN)C=C3C2=O)=O)=O.Cl
- Molecular Weight: 573.04
- References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, sealed storage, away from moisture and light)
- Clinical Information: No Development Reported