N1-Propargylpseudouridine
CAT:
804-HY-152659
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
N1-Propargylpseudouridine
- CAS Number: 1464021-70-2
- UNSPSC Description: N1-Propargylpseudouridine (see GL102032) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. N1-Propargylpseudouridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: Nucleoside Antimetabolite/Analog
- Type: Oligonucleotides
- Related Pathways: Cell Cycle/DNA Damage
- Applications: Cancer-programmed cell death
- Field of Research: Others
- Assay Protocol: https://www.medchemexpress.com/n1-propargylpseudouridine.html
- Solubility: 10 mM in DMSO
- Smiles: O[C@H]1[C@@H](O)[C@H](C(C(N2)=O)=CN(CC#C)C2=O)O[C@@H]1CO
- Molecular Weight: 282.25
- References & Citations: [1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported