6-Ethoxy-9-beta-D-(2-C-methyl-ribofuranosyl)purine

6-Ethoxy-9-beta-D-(2-C-methyl-ribofuranosyl)purine

• CAS Number: 848750-87-8
• UNSPSC Description: 6-Ethoxy-9-beta-D-(2-C-methyl-ribofuranosyl)purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
• Target Antigen: Nucleoside Antimetabolite/Analog
• Type: Oligonucleotides
• Related Pathways: Cell Cycle/DNA Damage
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/6-ethoxy-9-beta-d-2-c-methyl-ribofuranosyl-purine.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1[C@@](C)(O)[C@H](N(C=N2)C3=C2C(OCC)=NC=N3)O[C@@H]1CO
• Molecular Weight: 310.31
• References & Citations: [1]Virág L, Szabó C. Purines inhibit poly(ADP-ribose) polymerase activation and modulate oxidant-induced cell death. FASEB J. 2001 Jan;15(1):99-107.|[2]Saugstad OD. Hypoxanthine as an indicator of hypoxia: its role in health and disease through free radical production. Pediatr Res. 1988 Feb;23(2):143-50.|[3]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported