VEGFR-2/DHFR-IN-2

VEGFR-2/DHFR-IN-2

• CAS Number: 2831498-09-8
• UNSPSC Description: VEGFR-2/DHFR-IN-2 (compound 5b) is an inhibitor of VEGFR-2 and DHFR with IC50s of 0.623 and 9.085 μM, respectively. VEGFR-2/DHFR-IN-2 exhibits good cytotoxic activities against C26, HepG2, and MCF7 cancer cell lines with IC50 values of 3.59-8.38 μM. VEGFR-2/DHFR-IN-2 can be used for the research of cancer[1].
• Target Antigen: Bacterial; Dihydrofolate reductase (DHFR) ; Fungal; VEGFR
• Type: Reference compound
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/vegfr-2-dhfr-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(NCC1=CC=C(C)C=C1)C2=CC(O)=C3C(OC)=CC(OC)=CC3=C2
• Molecular Weight: 351.40
• References & Citations: [1]Pham EC, et al. Design, Microwave-Assisted Synthesis, Antimicrobial and Anticancer Evaluation, and In Silico Studies of Some 2-Naphthamide Derivatives as DHFR and VEGFR-2 Inhibitors. ACS. 2022.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported