EGFR/HER2-IN-8
CAT:
804-HY-151161
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
EGFR/HER2-IN-8
- CAS Number: 2820126-32-5
- UNSPSC Description: EGFR/HER2-IN-8 (compound 34) is a EGFR/HER2 and DHFR inhibitor. EGFR/HER2-IN-8 inhibits EGFR kinase, HER2 kinase and DHFR with IC50s of 0.45, 0.244 and 5.669 μM, respectively. EGFR/HER2-IN-8 shows anticancer activity against several cancer cell lines with high safety profile and selectivity indices. EGFR/HER2-IN-8 can be used for the research of cancer[1].
- Target Antigen: EGFR
- Type: Reference compound
- Related Pathways: JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/egfr-her2-in-8.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=CSC2=NC=C(C3=CC=C(C)C=C3)N21)NNC(CC)=O
- Molecular Weight: 328.39
- References & Citations: [1]Sabry MA, et al. New thiazole-based derivatives as EGFR/HER2 and DHFR inhibitors: Synthesis, molecular modeling simulations and anticancer activity. Eur J Med Chem. 2022 Aug 10;241:114661.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported