Tubulin polymerization-IN-9

Tubulin polymerization-IN-9

• CAS Number: 2485020-93-5
• UNSPSC Description: Tubulin polymerization-IN-9 is a potent tubulin inhibitor with IC50 of 1.82 μM. Tubulin polymerization-IN-9 causes cell cycle arrest at G2/M phase, and induces cell apoptosis and depolarized mitochondria of K562 cells. Tubulin polymerization-IN-9 has potent anti-vascular and antitumor activities[1].
• Target Antigen: Apoptosis; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tubulin-polymerization-in-9.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=CC([Se](=O)(/C=C/C2=CC=CC3=C2C=CN3)=O)=CC(OC)=C1OC
• Molecular Weight: 420.32
• References & Citations: [1]Zhu H, Sun H, Liu Y, et al. Design, synthesis and biological evaluation of vinyl selenone derivatives as novel microtubule polymerization inhibitors. Eur J Med Chem. 2020;207:112716.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported