β-S-ARCA

β-S-ARCA

• CAS Number: 1093268-63-3
• UNSPSC Description: β-S-ARCA is a mRNA 7-methylguanosine (m7G) cap analog carrying a phosphorothioate (PS) moiety. mRNAs incorporating β-S-ARCA have elongated cellular half-lives and showed augmented protein expression. β-S-ARCA D1 has been applied in researching experimental mRNA-based anticancer vaccines[1].
• Target Antigen: Others
• Type: Oligonucleotides
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/β-s-arca.html
• Solubility: 10 mM in DMSO
• Smiles: O=P(O)(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=O)O1)OP(OP(OC[C@@H]4[C@@H](O)[C@@H](OC)[C@H](N5C(NC(N)=N6)=C([N+](C)=C5)C6=O)O4)([O-])=O)(S)=O
• Molecular Weight: 832.52
• References & Citations: [1]Warminski M, et al. Structural Insights into the Interaction of Clinically Relevant Phosphorothioate mRNA Cap Analogs with Translation Initiation Factor 4E Reveal Stabilization via Electrostatic Thio-Effect. ACS Chem Biol. 2021 Feb 19;16(2):334-343.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported