5-Aminosalicylic acid-13C6 (hydrochloride)

5-Aminosalicylic acid-13C6 (hydrochloride)

• CAS Number: 1261398-47-3
• UNSPSC Description: 5-Aminosalicylic acid-13C6 hydrochloride (Mesalamine-13C6 hydrochloride; 5-ASA-13C6 hydrochloride) is the 13C labeled 5-Aminosalicylic Acidhydrochloride. 5-Aminosalicylic acid-13C6 hydrochloride acts as a PPARγ agonist, and also inhibits p21-activated kinase 1 (PAK1) and NF-κB[1][2][3].
• Target Antigen: NF-κB; PAK; PPAR
• Type: Isotope-Labeled Compounds
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease;NF-κB;Vitamin D Related/Nuclear Receptor
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/5-aminosalicylic-acid-13c6-hydrochloride.html
• Solubility: 10 mM in DMSO
• Smiles: OC([13C]1=[13C]([13CH]=[13CH][13C](N)=[13CH]1)O)=O.Cl
• Molecular Weight: 195.55
• References & Citations: [1]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015;1853(10 Pt A):2349-2360.|[2]Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013;34(11):2580-2586.|[3]Fang HM, et al. 5-aminosalicylic acid in combination with nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007;13(20):2872-2877.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported