mTOR/HDAC-IN-1

mTOR/HDAC-IN-1

• CAS Number: 2815286-02-1
• UNSPSC Description: mTOR/HDAC-IN-1 (Compound 50) is a selective mTOR and HDAC dual inhibitor with IC50 values of 0.49 and 0.91 nM against mTOR and HDAC1, respectively. mTOR/HDAC-IN-1 can be studied as an anti-cancer agent[1].
• Target Antigen: HDAC; mTOR
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/mtor-hdac-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC1=C(C(C2=CC=C(OC(N)=N3)C3=C2)=N4)C(N4CC(CC5)CCN5C6=NC=C(C(NO)=O)C=N6)=NC=N1
• Molecular Weight: 501.50
• References & Citations: [1]Mingming Zhang, et al. Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy. Bioorg Med Chem Lett. 2021 Oct 1;49:128286.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported