Thalidomide-amido-PEG2-NH2 (hydrochloride)
CAT:
804-HY-138858A
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Thalidomide-amido-PEG2-NH2 (hydrochloride)
- CAS Number: 2380273-73-2
- UNSPSC Description: Thalidomide-amido-PEG2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
- Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-amido-peg2-nh2-hydrochloride.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(COCCOCCN)NC1=CC=CC(C(N2C(C(N3)=O)CCC3=O)=O)=C1C2=O.[H]Cl
- Molecular Weight: 454.86
- References & Citations: [1]Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported