Methyltetrazine-SS-NHS
CAT:
804-HY-136033
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Methyltetrazine-SS-NHS
- UNSPSC Description: Methyltetrazine-SS-NHS is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Methyltetrazine-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
- Target Antigen: ADC Linker
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/methyltetrazine-ss-nhs.html
- Solubility: 10 mM in DMSO
- Smiles: CC1=NN=C(C2=CC=C(CNC(CCSSCCC(ON3C(CCC3=O)=O)=O)=O)C=C2)N=N1
- Molecular Weight: 490.56
- References & Citations: [1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported