Mitoxantrone (diacetate)

Mitoxantrone (diacetate)

• CAS Number: 70711-41-0
• UNSPSC Description: Mitoxantrone diacetate is a potent topoisomerase II inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity[1][2][3][4]. Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively[5].
• Target Antigen: Apoptosis; Endogenous Metabolite; Orthopoxvirus; PKC; Topoisomerase
• Type: Reference compound
• Related Pathways: Anti-infection;Apoptosis;Cell Cycle/DNA Damage;Epigenetics;Metabolic Enzyme/Protease;TGF-beta/Smad
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/mitoxantrone-diacetate.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C2=C(C(NCCNCCO)=CC=C2NCCNCCO)C(C3=C(O)C=CC(O)=C13)=O.O=C(C)O.O=C(C)O
• Molecular Weight: 564.58
• References & Citations: [1]Takeuchi N, et al. Inhibitory effect of mitoxantrone on activity of protein kinase C and growth of HL60 cells. J Biochem. 1992 Dec;112(6):762-7.|[2]Bellosillo B, et al. Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.|[3]Vibet S, et al. Differential subcellular distribution of mitoxantrone in relation to chemosensitization in two human breast cancer cell lines. Drug Metab Dispos. 2007 May;35(5):822-8.|[4]Fujimoto S, et al. Antitumor activity of mitoxantrone against murine experimental tumors: comparative analysis against various antitumor antibiotics. Cancer Chemother Pharmacol. 1982;8(2):157-62.|[5]Sharon E Altmann, et al. Inhibition of cowpox virus and monkeypox virus infection by mitoxantrone. Antiviral Res. 2012 Feb;93(2):305-308.
• Shipping Conditions: Room temperature
• Clinical Information: Launched