Login

CHMFL-ABL-039

CAT:
804-HY-126143
Size:
Inquire
Price:
Ask
For price, please contact [email protected]
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
CHMFL-ABL-039 - image 1

CHMFL-ABL-039

  • CAS Number: 2304344-56-5
  • UNSPSC Description: CHMFL-ABL-039 is a type II native ABL kinase and drug-resistant V299L mutant BCR-ABL inhibitor with the IC50s of 7.9 nM and 27.9 nM, respectively. CHMFL-ABL-039 is used in the research of chronic myeloid leukemia[1].
  • Target Antigen: Bcr-Abl
  • Type: Reference compound
  • Related Pathways: Protein Tyrosine Kinase/RTK
  • Applications: Cancer-Kinase/protease
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/chmfl-abl-039.html
  • Solubility: 10 mM in DMSO
  • Smiles: O=C(NC1=CN=C(NC(C2CC2)=O)C=C1)CC3=CC=C(NC(C4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C3
  • Molecular Weight: 594.63
  • References & Citations: [1]Wu J, et al. Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia(CML). Cancer Biol Ther. 2019;20(6):877-885.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported