DBCO-NHCO-PEG4-amine
CAT:
804-HY-124386
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
DBCO-NHCO-PEG4-amine
- CAS Number: 1255942-08-5
- UNSPSC Description: DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB?MMAE and DBCO-TRX?MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].
- Target Antigen: ADC Linker; PROTAC Linkers
- Type: ADC Related
- Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/dbco-nhco-peg4-amine.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)CCNC(CCOCCOCCOCCOCCN)=O
- Molecular Weight: 523.62
- References & Citations: [1]Spangler B, et al. Toward a Ferrous Iron-Cleavable Linker for Antibody-Drug Conjugates. Mol Pharm. 2018 May 7;15(5):2054-2059. .
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported