Ansatrienin B

Ansatrienin B

• CAS Number: 82189-04-6
• UNSPSC Description: Ansatrienin B (Mycotrienin II) is an ansamycin antibiotic isolated from?Streptomyces. Ansatrienin B is active against fungi and yeasts, but inactive against bacteria.Ansatrienin B displays antitumor antibiotic activity and can be used as an ADC Toxin[1][2].
• Target Antigen: Antibiotic; Bacterial
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-immunoregulation
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/ansatrienin-b.html
• Purity: 99.0
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1CCCCC1)N[C@@H](C(O[C@@H](C/C=C/C=C/C=C/[C@@H](C2)OC)[C@@H]([C@H](/C(C)=C\CCC3=CC(O)=CC(NC2=O)=C3O)O)C)=O)C
• Molecular Weight: 638.79
• References & Citations: [1]M Sugita, et al. Studies on Mycotrienin Antibiotics, a Novel Class of Ansamycins. I. Taxonomy, Fermentation, Isolation and Properties of Mycotrienins I and II. J Antibiot (Tokyo). 1982 Nov;35(11):1460-6.|[2]D Feuerbach, et al. Mycotrienins. A New Class of Potent Inhibitors of Osteoclastic Bone Resorption. J Biol Chem. 1995 Oct 27;270(43):25949-55.|[3]Yuriko Yamada, et al.Mycotrienin II, a Translation Inhibitor That Prevents ICAM-1 Expression Induced by Pro-Inflammatory Cytokines. J Antibiot (Tokyo). 2011 May;64(5):361-6.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported