PARP-2/1-IN-2

PARP-2/1-IN-2

• CAS Number: 912444-01-0
• UNSPSC Description: PARP-2/1-IN-2 (Compound 4a), the enantiomer of Veliparib (HY-10129), is a potent PARP inhibitor with Kis of 2 and 5 nM against PARP-2 and PARP-1, respectively. PARP-2/1-IN-2 has an EC50 of 3 nM in a cell based assay of PARP activity[1].
• Target Antigen: PARP
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Epigenetics
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/parp-2-1-in-2.html
• Solubility: 10 mM in DMSO
• Smiles: NC(C1=C2C(N=C([C@]3(C)CCCN3)N2)=CC=C1)=O
• Molecular Weight: 244.29
• References & Citations: [1]Ta LE, et al. A novel and selective poly (ADP-ribose) polymerase inhibitor ameliorates chemotherapy-induced painful neuropathy. PLoS One. 2013;8(1):e54161.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported