N-Deacetylcolchicine
CAT:
804-HY-121434
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
N-Deacetylcolchicine
- CAS Number: 3476-50-4
- UNSPSC Description: N-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. It is a derivative of the microtubule polymerization inhibitor Colchicine (HY-16569) and activates the GTPase activity of microtubules[1][2].
- Target Antigen: Microtubule/Tubulin
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/n-deacetylcolchicine.html
- Smiles: COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(OC)C3=O
- Molecular Weight: 357.40
- References & Citations: [1]Muzaffar, A., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 33(2), 567-571 (1990).|[2]Lin, et al. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. The Journal of Biological Chemisty 256(17), 9242-9245 (1981).
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported