Desmethyl Sibutramine (hydrochloride)
CAT:
804-HY-135615A-02
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Desmethyl Sibutramine (hydrochloride)
- CAS Number: 84467-94-7
- UNSPSC Description: Desmethyl Sibutramine hydrochloride, the secondary metabolite of Sibutramine, is an orally active norepinephrine transporter (NET) and serotonin transporter (SERT) inhibitor. Desmethyl Sibutramine hydrochloride can be used in the research of obesity and appetite suppressant[1][2][3][4].
- Target Antigen: Serotonin Transporter
- Type: Reference compound
- Related Pathways: Neuronal Signaling
- Field of Research: Metabolic Disease; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/desmethyl-sibutramine-hydrochloride.html
- Smiles: ClC1=CC=C(C2(C(CC(C)C)NC)CCC2)C=C1.Cl
- Molecular Weight: 302.28
- References & Citations: [1]Talbot PS, et, al. Brain serotonin transporter occupancy by oral sibutramine dosed to steady state: a PET study using (11)C-DASB in healthy humans. Neuropsychopharmacology. 2010 Feb;35(3):741-51. |[2]Luscombe GP, et, al. The contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. Neuropharmacology. 1989 Feb;28(2):129-34.|[3]Wang J, et, al. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2008 Jul;25(7):822-30.|[4]Ponnuru VS, et, al. Quantification of sibutramine and its two metabolites in human plasma by LC-ESI-MS/MS and its application in a bioequivalence study. J Pharm Anal. 2012 Aug;2(4):249-257.
- Shipping Conditions: Room Temperature