ML-SA5
CAT:
804-HY-152182-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
ML-SA5
- CAS Number: 2418670-70-7
- UNSPSC Description: ML-SA5 is a potent TRPML1 cation channel agonist that activates the entire endosomal TRPML1 (ML1) current in DMD myocytes with an EC50 of 285 nM and is more potent than ML-SA1. ML-SA5 has anticancer activity and can inhibit tumour growth[1].
- Target Antigen: TRP Channel
- Type: Reference compound
- Related Pathways: Membrane Transporter/Ion Channel;Neuronal Signaling
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/ml-sa5.html
- Solubility: DMSO : 125 mg/mL (ultrasonic)
- Smiles: O=S(NC1=C(N2CCCCC2)C(Cl)=CC=C1)(C3=CC=C(S(=O)(N(C)C)=O)C=C3)=O
- Molecular Weight: 457.99
- References & Citations: [1]Wanlu Du, et al. Lysosomal Zn2+ release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma. Cell Rep. 2021 Oct 19;37(3):109848. |[2]Lu Yu, et al. Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models. Sci Adv. 2020 Feb 7;6(6):eaaz2736.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported