CDK2/4-IN-1

CDK2/4-IN-1

• UNSPSC Description: CDK2/4-IN-1 (compound B-4a) is a CDK2/4 inhibitor and a tubulin polymerization inhibitor. CDK2/4-IN-1 can be used in cancer research[1].
• Target Antigen: CDK; Microtubule/Tubulin
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk2-4-in-1.html
• Smiles: O=C1C(OC)=C[C@@H]2C(C=C3)=C([C@H]1C4=C2C5=C(C=C(OC)C(OC)=C5OC)CC[C@@H]4NC(C)=O)C=C3C6=CC=C(OS(=O)(C(F)(F)F)=O)C([Si](C)(C)C)=C6
• Molecular Weight: 771.87
• References & Citations: [1]Iqbal Lone W, et al. Discovery of colchicine aryne cycloadduct as a potent molecule for the abrogation of epithelial to mesenchymal transition via modulating cell cycle regulatory CDK-2 and CDK-4 kinases in breast cancer cells. Bioorg Chem. 2024 Sep;150:107581.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported