P-gp/CDK2-IN-1
CAT:
804-HY-161776
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
P-gp/CDK2-IN-1
- UNSPSC Description: P-gp/CDK2-IN-1 (Compound 4j) is an inhibitor for is inhibitor for P-glycoprotein (P-gp) and for cyclin-dependent kinase-2 (CDK2). P-gp/CDK2-IN-1 inhibits the proliferation of cancer cells SW-480 and MCF-7 wit IC50 of 38.6 μM and 26.6 μM. P-gp/CDK2-IN-1 exhibits antioxidant efficacy with EC50 of 580 μM in DPPH experiment[1].
- Target Antigen: CDK; P-glycoprotein
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Membrane Transporter/Ion Channel
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/p-gp-cdk2-in-1.html
- Smiles: O=C(C1=C(N)OC(C=C(C)O2)=C(C2=O)C1C3=CC(OC)=C(OC)C(OC)=C3)OCC
- Molecular Weight: 417.41
- References & Citations: [1]Ranjbar S, et al., 5-Oxo-dihydropyranopyran derivatives as anti-proliferative agents; synthesis, biological evaluation, molecular docking, MD simulation, DFT, and in-silico pharmacokinetic studies. Heliyon. 2024 Apr 23;10(9):e29850.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported