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Deoxy-thalidomide-Pip-C-PIP-boc

CAT:
804-HY-161208
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Deoxy-thalidomide-Pip-C-PIP-boc - image 1

Deoxy-thalidomide-Pip-C-PIP-boc

  • CAS Number: 2963655-14-1
  • UNSPSC Description: Deoxy-thalidomide-Pip-C-PIP-boc is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. Deoxy-thalidomide-Pip-C-PIP-boc can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
  • Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
  • Type: Reference compound
  • Related Pathways: Apoptosis;Autophagy;PROTAC
  • Applications: Cancer-programmed cell death
  • Field of Research: cancer
  • Assay Protocol: https://www.medchemexpress.com/deoxy-thalidomide-pip-c-pip-boc.html
  • Solubility: 10 mM in DMSO
  • Smiles: O=C1NC(CCC1N2C(C3=C(C=C(C=C3)N4CCC(CC4)CN5CCN(CC5)C(OC(C)(C)C)=O)C2)=O)=O
  • Molecular Weight: 525.64
  • References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53.|[2]Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203.|[3]Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453.
  • Shipping Conditions: Room temperature
  • Clinical Information: No Development Reported