CD33/SIGLEC3 (Myeloid Cell Surface Antigen)

CD33/SIGLEC3 (Myeloid Cell Surface Antigen)

• CAS Number: 9007-83-4
• Gene Name: [CD33]
• NCBI Gene ID: 945
• Reactivity: Human
• Storage Conditions: Antibody with azide: store at 4 to 8 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.
• Other Gene Names: [CD33; CD33; p67; SIGLEC3; SIGLEC-3; SIGLEC3; Siglec-3]
• Short Name: [CD33/SIGLEC3]
• Other Product Names: [Myeloid cell surface antigen CD33; Myeloid cell surface antigen CD33; myeloid cell surface antigen CD33; CD33 molecule; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33]
• NCBI GI Number: 116241290
• NCBI Accession Number: P20138.2
• Uniprot Accession Number: P20138