p53 Tumor Suppressor Protein

p53 Tumor Suppressor Protein

• Gene Name: [TP53]
• NCBI Gene ID: 7157
• Reactivity: Human
  Does not react with Monkey or Rat.
• Storage Conditions: Antibody with azide: store at 2 to 8 degree C.
  Antibody without azide: store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 20-25) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
• Other Gene Names: [TP53; TP53; P53; BCC7; LFS1; BMFS5; TRP53; P53]
• Short Name: [p53 Tumor Suppressor Protein]
• Other Product Names: [cellular tumor antigen p53 isoform a; Cellular tumor antigen p53; cellular tumor antigen p53; tumor protein p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53]
• NCBI GI Number: 120407068
• NCBI Accession Number: NP_000537.3
• NCBI GB Accession Number: NP_000537.3
• Uniprot Accession Number: P04637