Histone H1 (Nuclear Marker)

Histone H1 (Nuclear Marker)

• Gene Name: [H1]
• NCBI Gene ID: 2670
• Reactivity: Human, Mouse, Rat. Others not known.
• Storage Conditions: Antibody with azide - store at 2 to 8 degree C.
  Antibody without azide - store at -20 to -80 degree C.
  Antibody is stable for 24 months. Non-hazardous. No MSDS required.
• Specificity: Eukaryotic histones are basic and water-soluble nuclear proteins that form hetero-octameric nucleosome particles by wrapping 146 base pairs of DNA in a left-handed super-helical turn sequentially to form chromosomal fiber. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form the octamer; formed of two H2A-H2B dimers and two H3-H4 dimers, forming two nearly symmetrical halves by tertiary structure. Over 80% of nucleosomes contain the linker Histone H1, derived from an intronless gene that interacts with linker DNA between nucleosomes and mediates compaction into higher order chromatin. Histones are subject to posttranslational modification by enzymes primarily on their N-terminal tails, but also in their globular domains. Such modifications include methylation, citrullination, acetylation, phosphorylation, sumoylation, ubiquitination and ADP-ribosylation.
• Other Gene Names: [GFAP; GFAP; ALXDRD; GFAP]
• Short Name: [Histone H1]
• Other Product Names: [glial fibrillary acidic protein isoform 2; Glial fibrillary acidic protein; glial fibrillary acidic protein; glial fibrillary acidic protein]
• NCBI GI Number: 196115290
• NCBI Accession Number: NP_001124491.1
• NCBI GB Accession Number: NM_001131019.2
• Uniprot Accession Number: P14136