Polymyxin B
CAT:
804-HY-149179-01
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Polymyxin B
- CAS Number: 1404-26-8
- UNSPSC Description: Polymyxin B is an antibiotic. Polymyxin B inhibits Gram-negative infections by binding to the LPS of the bacterial wall with high affinity. Polymyxin B neutralizes the effect of endotoxin. Polymyxin B induces bacterial death by increasing its permeability. Polymyxin B is used in endotoxemia research[1][3].
- Target Antigen: Antibiotic; Bacterial
- Type: Reference compound
- Related Pathways: Anti-infection
- Applications: COVID-19-immunoregulation
- Field of Research: Infection
- Assay Protocol: https://www.medchemexpress.com/polymyxin-b.html
- Solubility: H2O : 33.33 mg/mL (ultrasonic;adjust pH to 2 with HCl)
- Smiles: [Polymyxin B]
- References & Citations: [1]Martin EL, et al. Endotoxin removal: how far from the evidence? The EUPHAS 2 Project. Contrib Nephrol. 2010;167:119-125.|[2]Manchandani P, et al.Role of Renal Drug Exposure in Polymyxin B-Induced Nephrotoxicity. Antimicrob Agents Chemother. 2017 Mar 24;61(4):e02391-16. |[3]Cardoso LS, et al.Polymyxin B as inhibitor of LPS contamination of Schistosoma mansoni recombinant proteins in human cytokine analysis. Microb Cell Fact. 2007 Jan 3;6:1.Biomed Pharmacother. 2023 Nov 8:115856.|iScience. 2024 Sep 24;27(10):111027.|Prince of Songkla University. 2023 Dec.|ACS Nano. 2021 Mar 23;15(3):4173-4185.|Agronomy. 2024 Feb 8, 14(2), 351.|bioRxiv. 2024 Dec 2:2024.11.27.625634.|bioRxiv. 2024 May 10.|Int J Pharm. 2021 Dec 14;612:121356.|J Antimicrob Chemother. 2020 Sep 1;75(9):2609-2615.|Microbiol Spectr. 2022 Apr 27;10(2):e0273021.|Transl Psychiatry. 2022 Apr 7;12(1):146.
- Shipping Conditions: Room Temperature
- Clinical Information: Launched