Lenalidomide-Pip-butyn
CAT:
804-HY-169362
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Lenalidomide-Pip-butyn
- CAS Number: 2497589-76-9
- UNSPSC Description: Lenalidomide-Pip-butyn is Lenalidomide (HY-A0003)-based E3 ligase ligand-linker conjugate, and is used in the recruitment of CRBN protein. Lenalidomide-Pip-butyn can be connected to the ligand for protein to form PROTACs, such as the PROTAC STAT3 degrader SD-436 (HY-169360)[1].
- Target Antigen: E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/lenalidomide-pip-butyn.html
- Smiles: O=C(C(CC1)N(C2=O)CC3=C2C=CC=C3C#CCCC4CCNCC4)NC1=O
- Molecular Weight: 379.45
- References & Citations: [1]Renqi Xu, et al. Discovery of SD-436: A Potent, Highly Selective and Efficacious STAT3 PROTAC Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. J Med Chem. 2024 Nov 28;67(22):20495-20513.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported