Lenalidomide
CAT:
400-SIH-410-10MG
Size:
10 mg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Lenalidomide
- Background: Clinically, lenalidomide has proven to be effective in the treatment of multiple myeloma and other B cell diseases. It has the ability to selectively bind and ubiquitinate two lymphoid transcription factors, IKZF1 and IKZF2, via the CRBN-CRL4 ubiquitin ligase. This ultimately leads to the degradation of IKZF1 and IKZF2, which are both essential in myeloma cell survival.
- Description: Ubiquitin ligase inducer
- Product Name Alternative: 3-(7-amino-3-oxo-1H-isoindol-2-yl)piperidine-2,6-dione
- CAS Number: 191732-72-6
- UNSPSC: 41116105
- Source: Synthetic
- Purity: >98% (TLC); NMR (Conforms)
- Weight: 0.01
- Format: Powder
- Solubility: Soluble in DMSO (200 mM), Water (<1 mM) and Ethanol (<1 mM).
- Molecular Formula: C13H13N3O3
- Molecular Weight: 259.26
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Krönke J., et al. (2014) Science. 343(6168): 301-5. 2. Lu G., et al. (2014) Science. 343(6168): 305-9.