Wortmannin

Wortmannin

• Background: Wortmannin is a steroid metabolite from the fungi Penicillium funiculosum. It specifically and irreversibly inhibits phosphatidylinositol 3-kinase (PI3-K). This in turn has been shown to inhibit the metabolic effects of insulin, yet the insulin receptor kinase activity is not altered. Because PI3-K is involved in membrane trafficking, and membrane trafficking is important in autophagy, Wortmannin also inhibits autophagy.
• Description: Autophagy inhibitor
• Product Name Alternative: SL-2052, KY12420
• CAS Number: 19545-26-7
• UNSPSC: 41116105
• Source: Synthetic
• Purity: ≥98%
• Weight: 0.001
• Format: White to off-white solid.
• Solubility: Soluble in DMSO (50 mg/ml), methanol (5 mg/ml) or 100% ethanol (25 mg/ml).
• Molecular Formula: C23H24O8
• Molecular Weight: 428.44
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Powis G., et al. (1994). Cancer Res. 54(9): 2419-23. 2. Hazeki O., et al. (1996). J Lipid Mediat Cell Signal. 14(1-3): 259-61. 3. Lee A., et al. (1995). FEBS Lett. 361(1): 51-4. 4. Blommaart E. F., et al. (1997). Eur J Biochem. 243(1-2): 240-6.