SP600125
CAT:
400-SIH-381-50MG
Size:
50 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
SP600125
- Background: Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 µM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis.
- Description: Jnk inhibitor
- Product Name Alternative: Anthra(1,9-cd)pyrazol-6(2H)-one, 1,9-Pyrazoloanthrone
- CAS Number: 129-56-6
- UNSPSC: 41116105
- Source: Synthetic
- Purity: >98%
- Weight: 0.05
- Format: Yellow to brown solid
- Solubility: Soluble in DMSO or methanol
- Molecular Formula: C14H8N2O
- Molecular Weight: 220.2
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
- References & Citations: 1. Bennett B.L., et al. (2001) Proc. Natl. Acad. Sci. U.S.A. 98(24): 13681-6. 2. Schnabl B., et al. (2001) Hepatology. 34(5): 953-63. 3. Bain J., et al. (2003) Biochem. J. 371(Pt 1): 199-204. 4. Wang Y., et al. (2007) Life Sci. 80(22): 2067-75.