Taxol

Taxol

• Background: Paclitaxel is a mitotic inhibitor that promotes and stabilizes tubulin polymerization, causing cell cycle arrest (1). Induces autocatalytic activation of caspase-10 in CCRF-HSB-2 cells, triggering apoptosis (2).
• Description: Microtubule stabilizer
• Product Name Alternative: (2α,5β,7β,10β,13α)-4,10-Diacetoxy-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7-dihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate, Paclitaxel
• CAS Number: 33069-62-4
• UNSPSC: 41116105
• Source: Synthetic
• Purity: >98% (TLC); NMR (Conforms)
• Weight: 0.05
• Format: White solid
• Solubility: Soluble in DMSO, ethanol or acetonitrile
• Molecular Formula: C47H51NO14
• Molecular Weight: 853.9
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Wani M., Taylor H., Wall M., Coggon P., and McPhail A. (1971) J Am Chem Soc. 93(9): 2325-2327. 2. Park S.J., et al. (2004) J Biol Chem. 279(49): 51057-51067.