Fusidic acid (sodium salt)
CAT:
804-HY-B1350A-02
Size:
10 mM / 1 mL
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Fusidic acid (sodium salt)
- CAS Number: 751-94-0
- UNSPSC Description: Fusidic acid sodium salt is an orally available antibacterial agent that inhibits bacterial protein synthesis by preventing the release of translation elongation factor G (EF-G) from ribosomes. Fusidic acid sodium salt inhibits the inhibitory and activating effects of interleukins IL-1 and IL-6 on glucose-induced insulin production and exhibits antidiabetic effects in a rat model. Fusidic acid sodium salt improves the symptoms of colitis in rats and inhibits the growth of Toxoplasma gondii and Listeria monocytogenes EGD in vitro, but not in mice[1][2][3][4][5][6].
- Target Antigen: Antibiotic; Bacterial; Interleukin Related
- Type: Natural Products
- Related Pathways: Anti-infection;Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Infection; Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/Fusidic-acid-sodium-salt.html
- Purity: 99.64
- Solubility: DMSO : ≥ 100 mg/mL|H2O : ≥ 100 mg/mL
- Smiles: C[C@@H]([C@]1([H])CC[C@]([C@@](C[C@@H]/2OC(C)=O)3C)4C)[C@H](O)CC[C@]1(C)[C@]4([H])[C@H](O)C[C@@]3([H])C2=C(C(O[Na])=O)/CC/C=C(C)\C
- Molecular Weight: 538.69
- References & Citations: [1] J Turnidge, et al. Fusidic acid pharmacology, pharmacokinetics and pharmacodynamics. Int J Antimicrob Agents. 1999 Aug:12 Suppl 2:S23-34.|[2]P Collignon, et al. Fusidic acid in vitro activity. Int J Antimicrob Agents. 1999 Aug:12 Suppl 2:S45-58.|[3]K Bendtzen, et al. Effect of fusidic acid on interleukin-1 (IL-1)- and IL-6-induced pancreatic beta-cell functions in rats. J Endocrinol. 1992 Mar;132(3):345-52.|[4]Amanda J Payne, et al. Fusidic acid is an effective treatment against Toxoplasma gondii and Listeria monocytogenes in vitro, but not in mice. Parasitol Res. 2013 Nov;112(11):3859-63.|[5]K Buschard, et al. Anti-diabetogenic effect of fusidic acid in diabetes prone BB rats. Autoimmunity. 1992;14(2):101-4.|[6]Roberto Di Marco, et al. Curative effects of sodium fusidate on the development of dinitrobenzenesulfonic acid-induced colitis in rats. Clin Immunol. 2003 Dec;109(3):266-71.Adv Sci (Weinh). 2023 Jun 29;e2301753.|Cell Rep Med. 2023 May 24;101061.|Cell Rep Med. 2023 May 24;101061.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched