Hymeglusin

Hymeglusin

• CAS Number: 29066-42-0
• UNSPSC Description: Hymeglusin, as a fungal β-lactone antibiotic, is a HMG-CoA synthase inhibitor (IC50 = 0.12 μM). Hymeglusin covalently modifies the active Cys129 residue of the enzyme[2][3].
• Target Antigen: Antibiotic; Dengue virus; Flavivirus
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Cancer; Infection; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/hymeglusin.html
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: O=C(O)/C=C(C)/C=C(C)/C[C@H](C)CCCC[C@H]([C@H]1CO)OC1=O
• Molecular Weight: 324.41
• References & Citations: [1]Rothwell C, et al. Cholesterol biosynthesis modulation regulates dengue viral replication. Virology. 2009 Jun 20;389(1-2):18-19.|[2] Greenspan MD, et al. Inhibition of hydroxymethylglutaryl-coenzyme A synthase by L-659,699. Proc Natl Acad Sci U S A. 1987 Nov;84(21):7488-92.|[3] Tomoda H, et al. Binding site for fungal beta-lactone hymeglusin on cytosolic 3-hydroxy-3-methylglutaryl coenzyme A synthase. Biochim Biophys Acta. 2004 Feb 27;1636(1):22-8.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen, away from moisture)
• Clinical Information: No Development Reported