Anti-Hu CD367 Purified

Anti-Hu CD367 Purified

• Background: CD367 is an approximately 20-28 kDa C-type lectin with immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic part. CD367 binds in calcium-dependent manner to mannose, fucose, and weakly also to N-acetylglucosamine. It is expressed on dendritic cells, macrophages, monocytes, B cells, and neutrophils. In rheumatoid arthitis patients CD367 is expressed also on CD4+ T cells. After ligand-mediated triggering, it is internalized by clathrin-dependent endocytosis and contributes to the antigen presentation to CD8+ T cells. It may also be involved in modulation of the antigen presenting cell response.
• Specifications: The mouse monoclonal antibody 9E8 recognizes an extracellular epitope of human CD367, a type II transmembrane protein of C-lectin family, expressed mainly on antigen presenting cells.
• CAS Number: 9007-83-4
• Certification: RUO
• Host: Mouse
• Species Reactivity: Non-human primates, Human
• Immunogen: CD367 ectodomain fused with human Fc
• Target Antigen: CD367
• Isotype: Igg1 κ
• Clone: 9E8
• Applications: Flow cytometry: Recommended dilution: 1-4 µg/mL
• Validated Applications: ICC, FC, ELISA
• Concentration: 1 mg/mL
• Format: Purified
• Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• References & Citations: *Klechevsky E, Flamar AL, Cao Y, Blanck JP, Liu M, O'Bar A, Agouna-Deciat O, Klucar P, Thompson-Snipes L, Zurawski S, Reiter Y, Palucka AK, Zurawski G, Banchereau J: Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR. Blood 2010 Sep 9116(10):1685-97. , URL: https://pubmed.ncbi.nlm.nih.gov/20530286/,*Damasceno D, Andrés MP, van den Bossche WB, Flores-Montero J, de Bruin S, Teodosio C, van Dongen JJ, Orfao A, Almeida J: Expression profile of novel cell surface molecules on different subsets of human peripheral blood antigen-presenting cells. Clin Transl Immunology 2016 Sep 165(9):e100., URL: https://pubmed.ncbi.nlm.nih.gov/27766148/,*Autenrieth SE, Grimm S, Rittig SM, Grünebach F, Gouttefangeas C, Bühring HJ: Profiling of primary peripheral blood- and monocyte-derived dendritic cells using monoclonal antibodies from the HLDA10 workshop in Wollongong, Australia. Clin Transl Immunology 2015 Nov 134(11):e50. , URL: https://pubmed.ncbi.nlm.nih.gov/26682057/,
• Storage Conditions: Store at 2-8°C. Do not freeze.