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Regorafenib (monohydrate) (Standard)

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804-HY-10331AR
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Regorafenib (monohydrate) (Standard) - image 1

Regorafenib (monohydrate) (Standard)

  • CAS Number: 1019206-88-2
  • UNSPSC Description: Regorafenib (monohydrate) (Standard) is the analytical standard of Regorafenib (monohydrate). This product is intended for research and analytical applications. Regorafenib (BAY 73-4506) monohydrate is an orally active and potent multi-targeted receptor tyrosine kinase inhibitor, with IC50 values of 13/4.2/46, 22, 7, 1.5 and 2.5 nM for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1, respectively. Regorafenib monohydrate shows very robust antitumor and antiangiogenic activity[1].
  • Target Antigen: Autophagy; c-Kit; FGFR; PDGFR; Raf; RET; Tie; VEGFR
  • Type: Reference Standards
  • Related Pathways: Autophagy;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/regorafenib-monohydrate-standard.html
  • Smiles: O=C(NC1=CC=C(C(C(F)(F)F)=C1)Cl)NC2=CC=C(OC3=CC(C(NC)=O)=NC=C3)C=C2F.O
  • Molecular Weight: 500.83
  • References & Citations: [1]Wilhelm SM, et al. Regorafenib (BAY 73-4506): a new oral multikinase inhibitor of angiogenic, stromal and oncogenic receptor tyrosine kinases with potent preclinical antitumor activity. Int J Cancer, 2011, 129(1), 245-255.|[2]Heng DY, et al. Targeted therapy for metastatic renal cell carcinoma: current treatment and future directions. Ther Adv Med Oncol, 2010, 2(1), 39-49.|[3]Carr BI, et al. Fluoro-Bay 43-9006 (Regorafenib) effects on hepatoma cells: growth inhibition, quiescence, and recovery. J Cell Physiol, 2013, 228(2), 292-297.
  • Shipping Conditions: Room temperature