LRRK2/Dardarin Antibody
CAT:
400-SMC-445S
Size:
12 µg
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
LRRK2/Dardarin Antibody
- Background: LRRK2 is a large protein with multiple domains including several ankyrin, leucine-rich, and WD40 repeats, a Ras-like small GTPase family domain named Roc, and a kinase domain that is closely related to the RIP kinase domain. LRRK2 gene is expressed in brain as well as in other tissues such as lung, liver and heart. LRRK2 might be central to the pathogenesis of several major neurodegenerative diseases associated with parkinsonism. Several dominantly inherited missense mutations in the gene encoding LRRK2 have been identified in several families that exhibit a broad spectrum of neuropathological features.
- Description: Mouse Anti-Human LRRK2/Dardarin Monoclonal IgG2a
- Specifications: Detects >200kDa.
- Product Name Alternative: Leucine-rich repeat kinase 2 Antibody, RIP7 Antibody, PARK8 Antibody, Dardarin Antibody, ROCO 2 Antibody, RIPK7 Antibody, Leucine-rich repeat serine/threonine-protein kinase 2 Antibody, augmented in rheumatoid arthritis 17 Antibody
- Synonyms: LRRK2/Dardarin Antibody, Clone N231B/34
- CAS Number: 9007-83-4
- UNSPSC: 12352203
- Gene ID: 120892
- Swiss Prot: Q5S007
- Accession Number: NP_940980
- Cellular Locus: Cytoplasm | Membrane | Mitochondrion | Golgi Apparatus | Cell Projection | Axon | Dendrite | Endoplasmic Reticulum | Cytoplasmic Vesicle | Endosome | Lysosome
- Host: Mouse
- Species Reactivity: Human, Rat
- Immunogen: Fusion protein amino acids 841-960 of human LRRK2. 81% identical in mouse, 80% identical in rat. <30% identity with LRRK1.
- Target: LRRK2
- Clonality: Monoclonal
- Isotype: IgG2a
- Clone: N231B/34 (Formerly sold as S231B-34)
- Conjugation: Unconjugated
- Validated Applications: WB, ICC/IF, IHC
- Purification: Protein G Purified
- Limit Of Detection: 10 µg/ml of SMC-445 was sufficient for detection of LRRK2/Dardarin in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
- Concentration: 1 mg/ml
- Dilution: WB (1:100); optimal dilutions for assays should be determined by the user.
- Weight: 0.012
- Buffer: PBS pH7.4, 50% glycerol, 0.1% sodium azide
- Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.