LRP4 (Extracellular) Antibody: APC

LRP4 (Extracellular) Antibody: APC

• Background: Potential cell surface endocytic receptor, which binds and internalizes extracellular ligands for degradation by lysosomes. It is involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway.
• Description: Mouse Anti-Mouse LRP4 (Extracellular) Monoclonal IgG2A
• Specifications: Detects the extracellular domain of LRP4 ~215kDa. Degradation product can be seen at ~150kDa.
• Product Name Alternative: Corin Antibody, KIAA0816 Antibody, LDLR Antibody, LDLR dan Antibody, Low density lipoprotein receptor related protein 4 Antibody, LRP-4 Antibody, LRP10 Antibody, MEGF7 Antibody, Multiple epidermal growth factor like domains 7 Antibody
• Synonyms: LRP4 Antibody, Clone N207/27: APC
• CAS Number: 9007-83-4
• UNSPSC: 12352203
• Gene ID: 83469
• Swiss Prot: Q8VI56
• Accession Number: NP_766256.3
• Cellular Locus: Membrane
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Fusion protein amino acids 26- 350 (extracellular N-terminus) of mouse LTP4
• Target: LRP4
• Clonality: Monoclonal
• Isotype: IgG2A
• Clone: N207/27 (Formerly sold as S207-27)
• Conjugation: APC
• Validated Applications: IHC, ICC/IF
• Purification: Protein G Purified
• Limit Of Detection: 1 µg/ml of SMC-418 was sufficient for detection of LRP4 in 20 µg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.
• Concentration: 1 mg/ml
• Dilution: WB (1:1000), ICC/IF (1:100); optimal dilutions for assays should be determined by the user.
• Weight: 0.1
• Buffer: 95.64mM Phosphate, 2.48mM MES and 2mM EDTA
• Precautions: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
• References & Citations: 1. Bennett V., Baines A.J. (2001) Physiol. Rev. 81 (3): 1353–92.