CDDO-EA

CDDO-EA

• Product Name Alternative: CDDO ethyl amide; TP319; RTA 405
• CAS Number: 932730-51-3
• UNSPSC Description: CDDO-EA is an NF-E2 related factor 2/antioxidant response element (Nrf2/ARE) activator.
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/CDDO-EA.html
• Purity: 99.71
• Solubility: DMSO : 16.67 mg/mL (ultrasonic;warming;heat to 80°C)
• Smiles: O=C1C(C#N)=C[C@@]2(C)[C@](CC[C@]([C@@]3(C)[C@@]4([H])[C@@]5([H])[C@@](CCC(C)(C)C5)(C(NCC)=O)CC3)(C)C2=CC4=O)([H])C1(C)C
• Molecular Weight: 518.73
• References & Citations: [1]Neymotin A, et al. Neuroprotective effect of Nrf2/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med. 2011 Jul 1;51(1):88-96.|[2]Liby K, et al. The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. Cancer Res. 2007 Mar 15;67(6):2414-9.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported