O-Desmethyl-N-deschlorobenzoyl Indomethacin
CAT:
804-HY-W740572
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
O-Desmethyl-N-deschlorobenzoyl Indomethacin
- CAS Number: 50995-53-4
- UNSPSC Description: O-Desmethyl-N-deschlorobenzoyl indomethacin is a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor indomethacin (HY-14397). It is formed from indomethacin in isolated rabbit hepatocytes. O-Desmethyl-N-deschlorobenzoyl indomethacin (600 μM) decreases the viability of HL-60 leukemia cells when cultured with glucose oxidase. It has also been used in the synthesis of prostaglandin D2 (HY-101988) receptor antagonists.
- Target Antigen: COX; Prostaglandin Receptor
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Immunology/Inflammation
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/o-desmethyl-n-deschlorobenzoyl-indomethacin.html
- Smiles: CC1=C(CC(=O)O)C2=C(C=CC(=C2)O)N1
- Molecular Weight: 205.21
- References & Citations: [1]Torisu, et al. Discovery of new chemical leads for prostaglandin D2 receptor antagonists. Bioorg. Med. Chem. Lett. 14(17), 4557-4562 (2004).
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported