PROTAC BRD4-binding moiety 1
CAT:
804-HY-107442-03
Size:
25 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC BRD4-binding moiety 1
- CAS Number: 2101200-10-4
- UNSPSC Description: PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136)[1]. PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
- Target Antigen: Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
- Type: Reference compound
- Related Pathways: Epigenetics;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-brd4-binding-moiety-1.html
- Purity: 99.14
- Solubility: DMSO : 120 mg/mL (ultrasonic)
- Smiles: O=C1N(C)C2=C(C=C(C3=C(C)ON=C3C)C=C2)C(C4=CC=CC=C4)N1CC#C
- Molecular Weight: 371.43
- References & Citations: [1]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported