Pifithrin-μ
CAT:
804-HY-10940-02
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pifithrin-μ
- CAS Number: 64984-31-2
- UNSPSC Description: Pifithrin-μ is an inhibitor of p53 and HSP70, with antitumor and neuroprotective activity.
- Target Antigen: Autophagy; HSP; MDM-2/p53
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Applications: Cancer-programmed cell death
- Field of Research: Cancer; Neurological Disease
- Assay Protocol: https://www.medchemexpress.com/Pifithrin-_mu_.html
- Purity: 99.66
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=S(C#CC1=CC=CC=C1)(N)=O
- Molecular Weight: 181.21
- References & Citations: [1]Strom E, et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol. 2006 Sep;2(9):474-9. Epub 2006 Jul 23.|[2]Zhou Y, et al. Pifithrin-μ is efficacious against non-small cell lung cancer via inhibition of heat shock protein 70. Oncol Rep. 2017 Jan;37(1):313-322.|[3]Glas M, et al. Neuroprotection with the P53-Inhibitor Pifithrin-μ after Cardiac Arrest in a Rodent Model. Shock. 2018 Feb;49(2):229-234.
- Shipping Conditions: Blue Ice
- Storage Conditions: -20°C (Powder, stored under nitrogen)
- Clinical Information: No Development Reported