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CDK4/6-IN-15 (hydrochloride)

CAT:
804-HY-142076A-03
Size:
25 mg
Price:
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
CDK4/6-IN-15 (hydrochloride) - image 1

CDK4/6-IN-15 (hydrochloride)

  • UNSPSC Description: CDK4/6-IN-15 hydrochloride is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 hydrochloride potently inhibits cancer cells growth. CDK4/6-IN-15 hydrochloride arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression[1].
  • Target Antigen: CDK
  • Type: Reference compound
  • Related Pathways: Cell Cycle/DNA Damage
  • Applications: Cancer-Kinase/protease
  • Field of Research: Cancer
  • Assay Protocol: https://www.medchemexpress.com/cdk4-6-in-15-hydrochloride.html
  • Smiles: CNC1=NC(C)=C(C2=NC(NC3=NC=C(N4CCC(N(C)C)CC4)C=C3)=NC=C2F)S1.Cl
  • Molecular Weight: 479.02
  • References & Citations: [1]Tadesse S, et al. Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents. Br J Pharmacol. 2018 Jun;175(12):2399-2413.
  • Shipping Conditions: Room Temperature
  • Clinical Information: No Development Reported